Zebrafish with Lovesickness
Important Gene for Heart Growth Discovered
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A gene mutation in zebrafish triggers symptoms of lovesickness: the heart is badly damaged - it breaks, the body axis is "bent" and because of malformations in the gastric-intestinal tract, appetite dwindles. Dr. Wolfgang Rottbauer therefore named the mutation "lovesickness" or "lik" for short.

His work, however, does not deal with romantic feelings. Rather Dr. Rottbauer is researching the genetic causes of cardiovascular diseases.

The 34-year old scientist thus hopes to develop new drugs for heart attack patients. After a heart attack, the heart muscle is partly destroyed. Knowledge about the consequences of "lik" could aid in finding ways to grow healthy new tissue. The affected gene participates in a central signal pathway in the cell that regulates organ development.

 
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Zebrafish-Embryo. Below:
the heart - seen through a
microscope.
Why Zebrafish?

Dr. Rottbauer is not a downright fish lover. While he was a student he once shared a room wirh a goldfish, but the aquarium has long since been orphaned. "I have always been fascinated in embryonic development. That's why I've 'downsized' to zebrafish."

Zebrafish offer cardiovascular researchers a number of advantages: at the beginning of their development the small fish embryos are transparent. The heart function can therefore be observed under a light-optical microscope in the living fish. Moreover, in the first ten days of their life, the little fish are not dependent on a healthy heart. They survive despite heart defects and their development can be observed.

For the discovery of the "lovesickness"-gene and the explanation of its function, Dr. Rottbauer was honored with the Oskar-Lapp-Price 2003. Now he's searching for other cardiovascular diseases within the transparent zebrafish, for finding similarities of human's suffering.

 
 
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