Systematic Genome Research in the NGFN
The research on cancer, heart attack or Alzheimer’s and other complex diseases is only possible when not only one single gene but rather hundreds of genes or gene products (usually proteins) are systematically investigated.

In order to conduct such research at justifiable costs and in a reasonable timespan, scientists are dependent on sophisticated, high-throughput technology and appropriate data processing.

In the National Genome Research Network highly specialized experts apply these technologies and constantly develop them further. Here are some examples which demonstrate how important systematic genome research is for tracing the causes of diseases in the National Genome Research Network.


The NGFN launches one of the World’s Largest Studies to Discover Genetic Causes of 25 Diseases
The NGFN launches one of the World’s largest disease genetic research projects to date, which will investigate genetic variations that trigger complex diseases. Researchers will compare patients’ data with the data of healthy controls to identify genetic variations and differences associated with the diseases.
First Comprehensive Analysis of Human Chromosome 8
99.3% of the X-chromosome sequence is now deciphered. The deciphering will help us understand how the brain developed and to find new targets for therapies. The availability of the X chromosome sequence also offers a powerful insight into the evolution of the sex chromosomes.
A Small Deviation – A Great Diversity of Proteins
A human being does not have many more genes than a worm does. But human genes can produce many more proteins than a worm does. How does this work? Now NGFN researchers have been able to trace one of these mechanisms.
Unique Map Created of Human Protein Interactions
NGFN Researchers laid the foundation for the next important milestone in the history of medicine: They created a comprehensive connection scheme of the human body. The map helps us understand the functions of proteins and the complex processes in our cells.
Der kleine Unterschied zwischen Menschen und Schimpansen
The Secret of Disease-related Proteins
Cancer researchers in the NGFN are developing guidelines for systematically assembling the puzzle pieces of genome research to create a total picture. The publicly accessible Internet platform “LIFEdb” provides a wealth of information about the functions of genes and proteins – for the benefit of disease-oriented research.
About Beethoven and Other Mice
A tale of 15,000 small patients who had to undergo a thorough medical check-up. Why Beethoven didn’t pass the hearing test. And what can be learned from mice with eye diseases. A report from an unusual clinic near Munich.
Search Engine in the Gene Jungle
The human genome has been decoded. But how can the information be read? Where does a word begin and where does it end in this tremendous alphabet jumble? Where are the blueprints for proteins situated? And what functions do they have?
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Diseases of the Nervous System
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Diseases Due to Environmental Factors
 
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Cancer